Some because of their sinful lusts they indulge themselves in, and their contempt of the means of light and knowledge, and the stubborn choice they make of error and falsehood, are given up to judicial blindness and hardness of heart; as many among the heathens, who because they liked not to retain God in their knowledge, were given up to a reprobate mind, or to a mind void of judgment, and so imbibed notions and performed actions not convenient
There is in many an affected ignorance, which is very criminal; they are willingly ignorant, as the apostle says of the scoffers who shall arise in the last time, or rather they are unwilling to understand what they might, they know not, nor will they understand, they walk on in darkness; they do not choose to make use of but shun the means of knowledge, and shut their eyes against all light and conviction;
Ignorance, above other sins, enslaves a soul to Satan; a knowing man may be his slave, but an ignorant one can be no other. Knowledge does not make the heart good, but it is impossible that without knowledge it should be good. There are some sins which an ignorant person cannot commit; there are more which he cannot but commit.
I would rather confess my ignorance than falsely profess knowledge. It is no shame not to know all things, but it is a just shame to overreach in anything.
There are, as a learned man truly observes, two doors of the soul barred against Christ: the understanding by ignorance and the heart by hardness. Both these are opened by Christ. The former is opened by the preaching of the gospel, the other by the internal operation of the Spirit.
So indulgent is man toward himself, that, while doing evil, he always endeavors as much as he can to suppress the idea of sin. It was this, apparently, which induced Plato (in his Protagoras) to suppose that sins were committed only through ignorance.Institutes, Book 2, Chapter 2